Ning has a background in computer science and has worked for a number of years in the tech industry. She started the Innovo Foundation in 2004 and used that as a vehicle to drive her work in conservation, environmental education, and climate change mitigation. She collaborated with a Colorado non-profit and launched the ReNew Our School program to motivate K-12 students to save energy in school through education and friendly competition. The program has expanded nationally and was recognized as “the most impactful school climate action program in America'' by the Smart Electric Power Alliance.

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She was deeply engaged in Colorado’s 2018 midterm election and helped elect a pro-conservation state trifecta. Subsequently, she successfully advocated for historical climate and environmental bills in Colorado's legislative sessions in 2019 and after. In 2020, during the early months of the pandemic, she founded a 501(c)3 non-profit and fundraised, procured and distributed millions of Personal Protective Equipment to healthcare workers and low income and minority communities. In the same year, she also founded a 501(c)4 non-profit (Blue Wave Postcard Movement) and ran two dozen voter registration and GOTV postcard campaigns that reached more than 2.6 million households in eight battleground states. In 2021, she chaired the Democracy Alliance's Democracy Working Group and organized a group of national donors to advocate for the Freedom to Vote Act. In 2022, she launched a climate giving pledge for foundations and individuals (1.5°Climate Pledge) and a national climate donor collaborative (1.5°Climate Strategies Group) to help scale up the quantity and quality of climate giving.

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As an immigrant from China and a proud US citizen, Ning strongly believes in equity, diversity, inclusion, and fair representation. She started Emerging Voters to increase the civic engagement, protect the civil rights, and increase the representation of the AAPI communities.